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Karyopharm Therapeutics $KPTI cratered ~71% after its Phase 3 XPORT-EC-042 trial of selinexor (Xpovio) missed the primary progression-free survival endpoint in endometrial cancer, wiping out a key revenue driver. Shares collapsed from ~$7 to near $2, and Baird plus H.C. Wainwright both immediately downgraded to Neutral with $3 price targets. The company is cutting spending on the program and pivoting to myelofibrosis and multiple myeloma. Not financial advice. Does the remaining pipeline justify any position here, or is this one to avoid?
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