๐ง 60-Year-Old Diabetes Drug Metformin Secretly Works Through Your Brain, Not Just Your Liver
Scientists at Baylor College of Medicine discovered that metformin lowers blood sugar by switching off a protein called Rap1 in the brain's ventromedial hypothalamus โ not just through the liver and gut as believed for six decades. When mice were engineered to lack Rap1 in that brain region, the drug stopped working entirely. Published in Science Advances, this could reshape how smarter diabetes treatments are designed. Could targeting the brain unlock better therapies for the hundreds of millions living with type 2 diabetes?
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