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Vancomycin was once our go-to last-resort antibiotic โ until drug-resistant bacteria evolved ways to shrug it off entirely. Now, researchers at Scripps Research found a fix: pairing vancomycin with a small molecule called pghi-4, which blocks a key bacterial enzyme (SagA) that enables resistance. In lab studies, the combo successfully killed drug-resistant E. faecium again, and it marks the first ever "antibiotic adjuvant" developed specifically for vancomycin. Could this blueprint rescue other failing antibiotics too?