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Scientists assumed metformin lowered blood sugar by acting in the gut and liver β but a new study shows it also works quietly in your brain. Specifically, it activates neurons in the ventromedial hypothalamus by switching off a protein called Rap1, and tiny doses delivered directly to the brains of mice worked far better than full oral doses. The findings, published in Science Advances, open up a whole new front for designing diabetes drugs. What else might everyday medications be doing in our brains without us realizing?